Pyrexin Extra Overdosage

The clinical presentation of overdose may include tramadol toxicity signs and symptoms, paracetamol toxicity or both. Early symptoms seen in the first 24 hours, after paracetamol overdose: anorexia, nausea, vomiting, malaise, pallor and diaphoresis.
Tramadol: Potential and serious consequences of overdose of paracetamol components are respiratory depression, lethargy, coma, convulsions, cardiac arrest, and death.
Paracetamol: Severe cases of paracetamol overdoses may lead to liver toxicity in some patients. The initial symptoms after a potential overdose can result in hepatotoxic can include: gastrointestinal irritation, anorexia, nausea, vomiting, malaise, pallor and diaphoresis. Clinical and laboratory evidence of liver toxicity may not be apparent until 48-72 hours after ingestion.
Treatment: Maintain adequate ventilation together with supportive therapy. Steps must be taken to reduce drug absorption. Vomiting must be induced mechanically or with Ipecac syrup, if the patient is conscious (adequate pharyngeal and pharyngeal reflexes). Activated charcoal is given orally (1 g / kg should be carried out after gastric emptying). The first dose should be accompanied by appropriate catharsis. If repeated doses are used, catharsis may be included with alternative doses as needed. Hypotension is usually caused by hypovolemic conditions and must be treated with fluids Vasopressor and other supportive measures must be used as indicated: The endotracheal tube with a balloon must be inserted before gastric rinse in patients who are unconscious and if needed, to provide relief breathing.
In adult and child patients, every individual who comes with swallowed paracetamol whose number is unknown or with a history that is unclear or unpredictable about when it occurs should be sought for plasma paracetamol levels determined and treated with acetylcysteine.
If a measurement cannot be obtained and it is estimated that paracetamol consumption exceeds 7.5-10 gr for adults and adolescents or 150 mg / kg for children, then the administration of N-acetylcysteine should be initiated then continue with overall therapy.